Characterisation of lipid-protein interactions using a surface plasmon resonance biosensor

Surface plasmon resonance biosensor

Detection of Carcinoembryonic Antigens Using a Surface Plasmon Resonance Biosensor

Carcinoembryonic antigen (CEA) is an oncofoetal cell-surface glycoprotein that serves as an important tumor marker for colorectal and some other carcinomas. In this work, a CEA immunoassay using a surface plasmon resonance (SPR) biosensor has been developed. SPR could provide label-free, real-time detection with high sensitivity, though its ability to detect CEA in human serum was highly depend...

Characterization of drug-plasma protein interactions using surface plasmon resonance

Binding to plasma proteins is a key parameter in evaluating candidate compounds during the lead optimization and early ADME phases of the drug development process. Biacore’s surface plasmon resonance (SPR) technology is ideally suited for the analysis of multiple aspects of drug-plasma protein interactions. BiacoreS51 was used to analyze a panel of low molecular weight drug compounds for bindin...

Characterization of drug-plasma protein interactions using surface plasmon resonance

Binding to plasma proteins is a key parameter in evaluating candidate compounds during the lead optimization and early ADME phases of the drug development process. Surface plasmon resonance (SPR) technology is ideally suited for the analysis of multiple aspects of drug-plasma protein interactions. Here we describe how a BiacoreTM SPR based system was used to analyze a panel of low molecular wei...

Analysis of protein-DNA interactions using surface plasmon resonance.

Protein-DNA interactions are required for access and protection of the genetic information within the cell. Historically these interactions have been studied using genetic, biochemical, and structural methods resulting in qualitative or semiquantitative interaction data. In the future the focus will be on high quality quantitative data to model a huge number of interactions forming a specific n...